Modeling the dynamics of oral poliovirus vaccine cessation.

Improvement in the yield of oral poliovirus vaccine (Sabin strains) produced in human diploid cells

Modeling strategies to increase population immunity and prevent poliovirus transmission in the high-risk area of northwest Nigeria.

BACKGROUND Nigeria continues to struggle in its efforts to eliminate circulating live polioviruses using oral poliovirus vaccine (OPV). METHODS We modeled population immunity, and we estimated cases and the timing of transmission die-out for numerous policies that could accelerate the elimination of wild poliovirus type 1 (WPV1) and help Nigeria manage the risks of circulating vaccine-derived...

Managing the risk of circulating vaccine-derived poliovirus during the endgame: oral poliovirus vaccine needs

BACKGROUND The Global Polio Eradication Initiative plans for coordinated cessation of oral poliovirus vaccine (OPV) use, beginning with serotype 2-containing OPV (i.e., OPV2 cessation) followed by the remaining two OPV serotypes (i.e., OPV13 cessation). The risk of circulating vaccine-derived poliovirus (cVDPV) outbreaks after OPV cessation of any serotype depends on the serotype-specific popul...

Health and economic consequences of different options for timing the coordinated global cessation of the three oral poliovirus vaccine serotypes

BACKGROUND World leaders remain committed to globally-coordinated oral poliovirus vaccine (OPV) cessation following successful eradication of wild polioviruses, but the best timing and strategy for implementation depend on existing and emerging conditions. METHODS Using an existing integrated global poliovirus risk management model, we explore alternatives to the current timing plan of coordi...

Policy. OPV cessation--the final step to a "polio-free" world.

The 20-year, U.S. $4 billion-dollar international effort to eradicate wild polioviruses now includes monovalent oral poliovirus type 1 vaccine (mOPV1), which was first given to 40 million children in India in April 2005. As this vaccine is being introduced to eliminate some of the last poliovirus reservoirs, the Global Polio Eradication Initiative is planning for the eventual synchronized world...